Treatment Strategies and Perforation Rate of Acute Appendicitis During the Early Phase of the Covid-19 Pandemic: A Swedish Cohort StudyResearch article Published on 2022-12-012022-10-05 Journal: The Journal of surgical research [Category] 치료법, [키워드] 95% confidence interval Acute appendicitis Appendicitis association calculate Care Conservative management COVID-19 COVID-19 pandemic diagnosed early phase Frequency initial less multivariate logistic regression Odds ratio pandemic Patient patients hospitalized Perforation Perforation rate phase Rate receive resource Result risk severity single-center study South Strategy surgical Swedish Treatment Treatment strategies [DOI] 10.1016/j.jss.2022.07.007 [Article Type] Research article
Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A reviewArticle Published on 2022-11-302022-11-15 Journal: International journal of biological macromolecules [Category] SARS, 변종, 치료기술, 치료제, [키워드] accumulating addressed antiviral drug Care caused coronavirus SARS-CoV-2 diagnostic functions G-quadruplex Health Host Immune escape Intervention Ligand ligands neutralizing antibody nucleic acid pandemic polymerases protease Protein question recent regulate SARS-CoV-2 SARS-CoV-2 detection Structure targeting Targeting. Treatment strategies Vaccine variant virus virus [DOI] 10.1016/j.ijbiomac.2022.09.152 PMC 바로가기
Nucleocapsid Antigenemia Is a Marker of Acute SARS-CoV-2 InfectionArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 치료기술, [키워드] acute infection acute respiratory syndrome acute SARS-CoV-2 infection Analysis antigenemia Biomarker Blood coronavirus coronavirus disease COVID-19 determine Diagnosis ENhance exhibited Frequency highest individual Infection infection control infections Isolation nucleocapsid nucleocapsid. patients PCR polymerase chain reaction resolved retrospective RNA SARS-CoV-2 SARS-CoV-2 testing sensitivity seronegative Serosurvey severe disease specificity specimen Treatment Treatment strategies [DOI] 10.1093/infdis/jiac225 PMC 바로가기
Computational pharmacology: New avenues for COVID-19 therapeutics search and better preparedness for future pandemic crisesArticle Published on 2022-11-012022-11-16 Journal: Biophysical chemistry [Category] 신약개발, [키워드] affected analysis approach Cheminformatics clinical clinical study clinical trials complex compounds COVID-19 COVID-19 pandemic COVID-19 therapeutics deep learning develop Disease progression drug Drug repurposing drugs effort global healthcare Health help identify in silico Infectious disease information Intervention lack limitation machine machine learning miRNA MONITOR New pandemic pharmacological strategy Regulatory Research robust Side-effects System Systems biology systems biology. targets therapeutic therapeutic target Treatment strategies [DOI] 10.1016/j.bpc.2022.106891 PMC 바로가기
Procalcitonin as a predictive marker in COVID-19: A systematic review and meta-analysisArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] 바이오마커, [키워드] 95% CI clinical implications Coronavirus disease 2019 COVID-19 COVID-19 patients Critical case deaths decrease determine diagnostic discriminatory power disease severity global pandemic Handbook help identify item marker Meta-analysis methodology Mortality Odds ratio Patient patients patients with COVID-19 performed Predictive procalcitonin prognostic Reporting retrospective cohort study review robust sensitivity Severe case severity specificity systematic review Treatment Treatment strategies while [DOI] 10.1371/journal.pone.0272840 PMC 바로가기
Rhinovirus/enterovirus was the most common respiratory virus detected in adults with severe acute respiratory infections pre-COVID-19 in Kuala Lumpur, MalaysiaArticle Published on 2022-09-022022-11-15 Journal: PLoS ONE [Category] 치료기술, [키워드] Acute respiratory infection aetiology Analysis Asia Bacterial bacterial pathogen Blood contribute COVID-19 pandemic Critical disease Culture determine diagnostic effective Gender increased risk Influenza virus investigated lack Lung disease Malaysia male MERS-CoV Molecular assay Neurological disease Patient PCR positive predictor Prevalence qPCR assays respiratory pathogen Respiratory pathogens respiratory virus respiratory virus SARS-CoV sore throat Surveillance Treatment strategies virus was performed [DOI] 10.1371/journal.pone.0273697 PMC 바로가기
Dynamic Alterations in the Respiratory Tract Microbiota of Patients with COVID-19 and its Association with Microbiota in the GutArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] 바이오마커, [키워드] Actinomyces alteration analyzed Bacteroide Biomarker Candida contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression determine Diagnosis disease Disease progression disease severity dynamic Enterococcus Fecal sample Gut gut microbiota ICU ICU Patients identify immune response Increases intensive care intensive care unit metagenome microbe microbial Microbiome microbiota mononuclear cell non-ICU pathway Patient patients patients with COVID-19 PBMC Peripheral blood positive correlation reduced respiratory respiratory microbiota. respiratory tract sequenced Significant significantly sputum Stage Streptococcus tract Treatment strategies with COVID-19 [DOI] 10.1002/advs.202200956 PMC 바로가기
Clinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysisCOVID-19 돌발 감염의 임상 양상: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Analysis asymptomatic infection Breakthrough infection breakthrough infections clinical manifestation clinical manifestations Clinical outcome Coronavirus 2019 COVID-19 COVID-19 infection COVID-19 infections Delta delta variant Effect Effectiveness examined groups heterogeneity Hospitalization individual individuals Infection Invasive mechanical ventilation Meta-analysis Mortality need for oxygen other variants oxygen oxygen supplementation Patient Relative risk risk Risk factors risk of infection significantly significantly higher statistically statistically significant difference Still study heterogeneity supplemental oxygen systematic review Treatment strategies Vaccine vaccine effectiveness. variant variants Web of Science [DOI] 10.1002/jmv.27871 PMC 바로가기 [Article Type] Meta-Analysis
Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19Research article Published on 2022-08-242022-10-05 Journal: EBioMedicine [Category] SARS, 진단, 치료기술, [키워드] alveolar damage analysis Autopsy Bacteria Candida parapsilosis CD8+ T cells CD8+T cells Cell changes in complex correlated COVID-19 COVID-19 case COVID-19 patients DAD diffuse Diffuse alveolar damage disease eight elevated enriched pathway exhibit Extracellular matrix Factor fatal COVID-19 feature fibroblasts finding foundation funding fungi heart heterogeneity histological humoral immune immune cells immunohistochemistry immunological immunopathology implication innate immune response Lung disease lung tissue Lungs Macrophage macrophages management Melinda Gate modulate molecular multiplex occur Patient performed progression quantified Regeneron Pharmaceuticals response SARS-CoV-2 Secondary infection subsequent Support Swedish the disease Transcriptome Treatment strategies [DOI] 10.1016/j.ebiom.2022.104229 [Article Type] Research article
A simple model of COVID-19 explains disease severity and the effect of treatments Research Published on 2022-08-202022-10-05 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, 치료제, [키워드] Administered administration Analysis Antiviral Asymptomatic Cell Clinical finding Clinical outcome condition COVID-19 damage-associated molecular pattern damaged cell DAMP DAMPs disease severity dysregulated effect of treatment effort explain expressing hyperinflammation hypoxia infected cell Infection Inflammation interferon response lack less likelihood mathematical molecular natural killer cell Neutrophil extracellular traps PAMP PAMPs pathogen pathogen-associated molecular pattern pathogenesis of COVID-19 producing SARS-COV-2 infection severe COVID-19 Treatment Treatment strategies Viral load [DOI] 10.1038/s41598-022-18244-2 [Article Type] Research